Article
The Influence of the CTIP Polymorphism, Q418P, on Homologous Recombination and Predisposition to Radiation-Induced Tumorigenesis (mainly rAML) in Mice.
Radiation research - 1 Dec 2016
Patel Agata, Anderson Jennifer, Kraft Daniela, Finnon Rosemary, Finnon Paul, Scudamore Cheryl L, Manning Grainne, Bulman Robert, Brown Natalie, Bouffler Simon, O'Neill Peter, Badie Christophe
Abstract excerpt
Exposure to ionizing radiation increases the incidence of acute myeloid leukemia (AML), which has been diagnosed in Japanese atomic bombing survivors, as well as patients treated with radiotherapy. The genetic basis for susceptibility to radiation-induced AML is not well characterized. We previously identified a candidate murine gene for susceptibility to radiation-induced AML (rAML): C-terminal binding protein...
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