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Article

BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2010

Talati M, West J, Blackwell T R, Loyd J E, Meyrick B

Abstract excerpt

Macrophage derived-endothelin-1 (ET-1) has been suggested to contribute to a number of chronic lung diseases. Whether the ET-1 cascade from non-vascular sources (inflammatory cells) also contributes to pulmonary artery hypertension (PAH) and in particular to heritable PAH (HPAH) with known bone morphogenetic protein type 2 receptor (BMPR2) mutations is not known. We tested this notion using bone marrow-derived...

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Share to Aspartic Acid Endopeptidases
Share to Bone Morphogenetic Protein Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertension, Pulmonary

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Source

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Identifiers

PMID: 20562228
DOI: 10.1152/ajplung.00295.2009
PMCID: PMC2951074

Genes

BMPR2
PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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