Article
Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers.
Inflammatory bowel diseases - 1 Apr 2012
Olaru Alexandru V, Cheng Yulan, Agarwal Rachana, Yang Jian, David Stefan, Abraham John M, Yu Wayne, Kwon John H, Lazarev Mark, Brant Steven R, Marohn Michael R, Hutcheon David F, Harpaz Noam, Meltzer Stephen J, Mori Yuriko
Abstract excerpt
BACKGROUND: CpG island (CGI) hypermethylation at discrete loci is a prevalent cancer-promoting abnormality in sporadic colorectal carcinomas (S-CRCs). We investigated genome-wide CGI methylation in inflammatory bowel disease (IBD)-associated CRCs (IBD-CRCs). METHODS: Methylation microarray analyses were conducted on seven IBD-CRCs, 17 S-CRCs, and eight normal control colonic tissues from patients without CRC or...
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