Article
Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.
International journal of cancer - 1 Nov 2010
An Byonggu, Kondo Yutaka, Okamoto Yasuyuki, Shinjo Keiko, Kanemitsu Yukihide, Komori Koji, Hirai Takashi, Sawaki Akira, Tajika Masahiro, Nakamura Tsuneya, Yamao Kenji, Yatabe Yasushi, Fujii Makiko, Murakami Hideki, Osada Hirotaka, Tani Tohru, Matsuo Keitaro, Shen Lanlan, Issa Jean-Pierre J, Sekido Yoshitaka
Abstract excerpt
Aberrant DNA methylation is involved in colon carcinogenesis. Although the CpG island methylator phenotype (CIMP) is defined as a subset of colorectal cancers (CRCs) with remarkably high levels of DNA methylation, it is not known whether epigenetic processes are also involved in CIMP-negative tumors. We analyzed the DNA methylation profiles of 94 CRCs and their corresponding normal-appearing colonic mucosa with...
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