Article
LGI2 truncation causes a remitting focal epilepsy in dogs.
PLoS genetics - 1 Jul 2011
Seppälä Eija H, Jokinen Tarja S, Fukata Masaki, Fukata Yuko, Webster Matthew T, Karlsson Elinor K, Kilpinen Sami K, Steffen Frank, Dietschi Elisabeth, Leeb Tosso, Eklund Ranja, Zhao Xiaochu, Rilstone Jennifer J, Lindblad-Toh Kerstin, Minassian Berge A, Lohi Hannes
Abstract excerpt
One quadrillion synapses are laid in the first two years of postnatal construction of the human brain, which are then pruned until age 10 to 500 trillion synapses composing the final network. Genetic epilepsies are the most common neurological diseases with onset during pruning, affecting 0.5% of 2-10-year-old children, and these epilepsies are often characterized by spontaneous remission. We previously described...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.