Article
Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene.
BMC genomics - 18 Jun 2015
Koskinen Lotta L E, Seppälä Eija H, Belanger Janelle M, Arumilli Meharji, Hakosalo Osmo, Jokinen Päivi, Nevalainen Elisa M, Viitmaa Ranno, Jokinen Tarja S, Oberbauer Anita M, Lohi Hannes
Abstract excerpt
BACKGROUND: Idiopathic epilepsy is a common neurological disease in human and domestic dogs but relatively few risk genes have been identified to date. The seizure characteristics, including focal and generalised seizures, are similar between the two species, with gene discovery facilitated by the reduced genetic heterogeneity of purebred dogs. We have recently identified a risk locus for idiopathic epilepsy in...
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