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Article

Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy.

Epilepsia - 1 Jul 2026

Lal Jessica Castrillon, Leu Costin, Boßelmann Christian M, Ivaniuk Alina, Pérez-Palma Eduardo, Lal Dennis

Abstract excerpt

Epilepsy affects more than 50 million individuals globally and has a substantial genetic component that remains to be completely understood. Traditional studies have focused on severe, early onset cases enrolled through clinical or research settings. Recent biobank-based approaches, leveraging large-scale population datasets, offer opportunities to explore genetic associations in broader epilepsy phenotypes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42216960
DOI: 10.1002/epi.70299
PMCID: PMC13360984

Genes

ADAM23
LGI1
ATP1A3
GABRG2
HTRA2
PDCD4
STAG1
TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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