Article
ADAM23 is a common risk gene for canine idiopathic epilepsy.
BMC genetics - 31 Jan 2017
Koskinen Lotta L E, Seppälä Eija H, Weissl Jutta, Jokinen Tarja S, Viitmaa Ranno, Hänninen Reetta L, Quignon Pascale, Fischer Andrea, André Catherine, Lohi Hannes
Abstract excerpt
BACKGROUND: Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds....
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