Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status.

doi:10.1158/1055-9965.EPI-13-0635-T

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Article

Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2014

Pooley Karen A, McGuffog Lesley, Barrowdale Daniel, Frost Debra, Ellis Steve D, Fineberg Elena, Platte Radka, Izatt Louise, Adlard Julian, Bardwell Julian, Brewer Carole, Cole Trevor, Cook Jackie, Davidson Rosemarie, Donaldson Alan, Dorkins Huw, Douglas Fiona, Eason Jacqueline, Houghton Catherine, Kennedy M John, McCann Emma, Miedzybrodzka Zosia, Murray Alex, Porteous Mary E, Rogers Mark T, Side Lucy E, Tischkowitz Marc, Walker Lisa, Hodgson Shirley, Eccles Diana M, Morrison Patrick J, Evans D Gareth, Eeles Rosalind A, Antoniou Antonis C, Easton Douglas F, Dunning Alison M

Abstract excerpt

BACKGROUND: Telomere length has been linked to risk of common diseases, including cancer, and has previously been proposed as a biomarker for cancer risk. Germline BRCA1 and BRCA2 mutations predispose to breast, ovarian, and other cancer types. METHODS: We investigated telomere length in BRCA mutation carriers and their non-carrier relatives and further examined whether telomere length is a modifier of cancer...

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PMID: 24642354
DOI: 10.1158/1055-9965.EPI-13-0635-T
PMCID: PMC4266102

Genes

BRCA2
BRCA1
IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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