Article
Telomere shortening is associated with genetic anticipation in Chinese Von Hippel-Lindau disease families.
Cancer research - 15 Jul 2014
Ning Xiang-Hui, Zhang Ning, Li Teng, Wu Peng-Jie, Wang Xi, Li Xue-Ying, Peng Shuang-He, Wang Jiang-Yi, Chen Jin-Chao, Gong Kan
Abstract excerpt
Von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome. A phenomenon known as genetic anticipation has been documented in some hereditary cancer syndromes, where it was proved to relate to telomere shortening. Because studies of this phenomenon in VHL disease have been relatively scarce, we investigated anticipation in 18 Chinese VHL disease families. We recruited 34 parent-child patient...
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