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Article

Antipsychotic drug dosage and therapeutic response in schizophrenia is influenced by ABCB1 genotypes: a study from a south Indian perspective.

Pharmacogenomics - 1 Jul 2012

Vijayan Neetha N, Mathew Anila, Balan Shabeesh, Natarajan Chandrasekhar, Nair Chandrashekharan M, Allencherry Priya M, Banerjee Moinak

Abstract excerpt

AIM: The conventional practice of using trial and error mode to select antipsychotic drugs in treatment of schizophrenia can result in symptom exacerbations, relapse and severe side effects, resulting in higher costs of treatment. P-glycoprotein (ABCB1) is known to regulate the concentration of antipsychotic drugs in the brain. Variable expressivity based on polymorphism in the gene ABCB1 may reflect on the drug...

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Source

Identifiers

PMID: 22909202
DOI: 10.2217/pgs.12.86

Genes

ABCB1

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