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Article

Intermolecular alignment in Y145Stop human prion protein amyloid fibrils probed by solid-state NMR spectroscopy.

Journal of the American Chemical Society - 7 Sept 2011

Helmus Jonathan J, Surewicz Krystyna, Apostol Marcin I, Surewicz Witold K, Jaroniec Christopher P

Abstract excerpt

The Y145Stop mutant of human prion protein, huPrP23-144, has been linked to PrP cerebral amyloid angiopathy, an inherited amyloid disease, and also serves as a valuable in vitro model for investigating the molecular basis of amyloid strains. Prior studies of huPrP23-144 amyloid by magic-angle-spinning (MAS) solid-state NMR spectroscopy revealed a compact β-rich amyloid core region near the C-terminus and an...

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Identifiers

PMID: 21827207
DOI: 10.1021/ja206469q
PMCID: PMC3164902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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