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Article

Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease-associated T183A variant.

Biomolecular NMR assignments - 1 Apr 2021

Sanz-Hernández Máximo, De Simone Alfonso

Abstract excerpt

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders associated with the misfolding and aggregation of the human prion protein (huPrP). Despite efforts into investigating the process of huPrP aggregation, the mechanisms triggering its misfolding remain elusive. A number of TSE-associated mutations of huPrP have been identified, but their role at the onset and progression of prion...

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Identifiers

PMID: 33590433
DOI: 10.1007/s12104-021-10005-y
PMCID: PMC7974147

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