Article

Structural details of amyloid beta oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

2020-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Human PrP (huPrP) is a high-affinity receptor for oligomeric Aβ. Synthetic oligomeric Aβ species are known to be heterogeneous, dynamic and transient, rendering their structural investigation particularly challenging. Here, we used huPrP to preserve Aβ oligomers by co-precipitating them into large hetero-assemblies to investigate the conformation of Aβ(1-42) oligomers and huPrP in the complex by...

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Literature Corpus work: 616f006a-6163-5dc4-aa2b-7f04fc32d91f
DOI: 10.1101/2020.06.22.164574

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