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Article

13C and 15N chemical shift assignments of A117V and M129V human Y145Stop prion protein amyloid fibrils.

Biomolecular NMR assignments - 1 Apr 2021

Dao Hanh H, Hlaing May Z, Ma Yixuan, Surewicz Krystyna, Surewicz Witold K, Jaroniec Christopher P

Abstract excerpt

The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro model for investigating the molecular basis of amyloid strains and cross-seeding barriers. Here,...

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Identifiers

PMID: 33123960
DOI: 10.1007/s12104-020-09981-4
PMCID: PMC7979434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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