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Article

Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck.

Pharmacogenetics and genomics - 1 Jul 2011

Yu Hongping, Wang Li-E, Liu Zhensheng, Wei Sheng, Li Guojun, Sturgis Erich M, Wei Qingyi

Abstract excerpt

PURPOSE: Mouse double minute 4 (MDM4), a homolog of MDM2, is one of the key negative regulators of p53, and its amplification or overexpression contributes to carcinogenesis by inhibiting the p53 tumor suppressor activity. We investigated the association between MDM4 polymorphisms and the risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: We genotyped three MDM4 tagging polymorphisms, two in...

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Share to Carcinoma
Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Squamous Cell

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Source

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Identifiers

PMID: 21540763
DOI: 10.1097/FPC.0b013e32834632e4
PMCID: PMC3116079

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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