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Human Papillomavirus Seropositivity Synergizes with<i>MDM2</i>Variants to Increase the Risk of Oral Squamous Cell Carcinoma

25 Aug 2010

Abstract excerpt

The increasing incidence of oral squamous cell carcinoma (OSCC) in young adults has been associated with sexually transmitted infections of human papillomavirus (HPV), particularly HPV16. Given the roles of p53 in tumor suppression and of HPV E6 and MDM2 oncoproteins in p53 degradation, we evaluated HPV16 L1 seropositivity and MDM2 promoter variants to examine their possible associations with OSCC risk in a...

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PMID: 20736372
DOI: 10.1158/0008-5472.can-09-4733

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