Article
Asp159 is a critical core amino acid of an IgE-binding and cross-reactive epitope of a dust mite allergen Der f 7.
Molecular immunology - 1 Sept 2011
Chou H, Tam M F, Lee S-S, Tang R-B, Lin T-H, Tai H-Y, Chen Y-S, Shen H-D
Abstract excerpt
Der f 7 and Der p 7 are important house dust mite allergens with known structure and suggested biological function recently. However, their IgE-binding determinants remain unknown. The purpose of this study is to identify the IgE-reactive epitopes of Der f 7 and the determinants of IgE-mediated cross-reactivity between Der f 7 and Der p 7. IgE-reactive determinants were identified by immunodot blot inhibition...
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