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Article

Molecular determinants for antibody binding on group 1 house dust mite allergens.

The Journal of biological chemistry - 2 Mar 2012

Chruszcz Maksymilian, Pomés Anna, Glesner Jill, Vailes Lisa D, Osinski Tomasz, Porebski Przemyslaw J, Majorek Karolina A, Heymann Peter W, Platts-Mills Thomas A E, Minor Wladek, Chapman Martin D

Abstract excerpt

House dust mites produce potent allergens, Der p 1 and Der f 1, that cause allergic sensitization and asthma. Der p 1 and Der f 1 are cysteine proteases that elicit IgE responses in 80% of mite-allergic subjects and have proinflammatory properties. Their antigenic structure is unknown. Here, we present crystal structures of natural Der p 1 and Der f 1 in complex with a monoclonal antibody, 4C1, which binds to a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22210776
DOI: 10.1074/jbc.M111.311159
PMCID: PMC3293536

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Source receipt: pubmed, retrieved 7 Sept 2026.

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