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Article

Hypoallergenic Variant of the Major Egg White Allergen Gal d 1 Produced by Disruption of Cysteine Bridges.

Nutrients - 21 Feb 2017

Dhanapala Pathum, Withanage-Dona Dulashi, Tang Mimi L K, Doran Tim, Suphioglu Cenk

Abstract excerpt

BACKGROUND: Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic variants of this allergen can be used in immunotherapy as an egg allergy treatment approach. We hypothesised that disruption of two of the nine cysteine-cysteine bridges by site-directed mutagenesis will allow the production of a hypoallergenic variant of the protein; Methods: Two cysteine residues at C192 and C210...

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PMID: 28230769
DOI: 10.3390/nu9020171
PMCID: PMC5331602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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