Article
Development of hypoallergenic variants of the major horse allergen Equ c 1 for immunotherapy by rational structure based engineering.
Scientific reports - 27 Dec 2019
Haka Jaana, Niemi Merja H, Mattila Pekka, Jänis Janne, Takkinen Kristiina, Rouvinen Juha
Abstract excerpt
The use of recombinant allergens is a promising approach in allergen-specific immunotherapy (AIT). Considerable limitation, however, has been the ability of recombinant allergens to activate effector cells leading to allergic reactions. Recombinant hypoallergens with preserved protein folding and capacity to induce protective IgG antibodies binding effectively to the native allergen upon sensitization would be...
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