Article
IgE binding conformational epitopes of Asp f 3, a major allergen of Aspergillus fumigatus.
Clinical immunology (Orlando, Fla.) - 1 Jun 2002
Ramachandran Harikrishnan, Jayaraman Vasanthi, Banerjee Banani, Greenberger Paul A, Kelly Kevin J, Fink Jordan N, Kurup Viswanath P
Abstract excerpt
sp f 3 has been identified as one of the major allergens of Aspergillus fumigatus associated with the sensitization and immune responses in allergic bronchopulmonary aspergillosis (ABPA). In order to understand the structure/function relationship of Asp f 3, we studied synthetic peptides and constructed mutants deleted of specific IgE binding regions. The mutated allergens were obtained by expressing the genes...
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