Article
Effect of host and viral factors on hepatitis B e antigen-positive chronic hepatitis B patients receiving pegylated interferon-α-2a therapy.
Antiviral therapy - 1 Jan 2011
Tseng Tai-Chung, Yu Ming-Lung, Liu Chun-Jen, Lin Chih-Lin, Huang Yi-Wen, Hsu Ching-Sheng, Liu Chen-Hua, Kuo Stephanie Fang-Tzu, Pan Corinna Jen-Hui, Yang Sheng-Shun, Su Chien-Wei, Chen Pei-Jer, Chen Ding-Shinn, Kao Jia-Horng
Abstract excerpt
BACKGROUND: Pegylated interferon (PEG-IFN)-α-2a improves the hepatitis B e antigen (HBeAg) seroconversion rate in HBeAg-positive chronic hepatitis B patients. However, baseline factors predicting favourable responses to PEG-IFN-α-2a remain largely unknown. METHODS: A total of 115 HBeAg-positive chronic hepatitis B patients who had a pre-therapy serum alanine aminotransferase (ALT) level over two times the upper...
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