Article
Relevance of baseline viral genetic heterogeneity and host factors for treatment outcome prediction in hepatitis C virus 1b-infected patients.
PloS one - 1 Jan 2013
Saludes Verónica, Bascuñana Elisabet, Jordana-Lluch Elena, Casanovas Sònia, Ardèvol Mercè, Soler Esther, Planas Ramón, Ausina Vicente, Martró Elisa
Abstract excerpt
BACKGROUND: Only about 50% of patients chronically infected with HCV genotype 1 (HCV-1) respond to treatment with pegylated interferon-alfa and ribavirin (dual therapy), and protease inhibitors have to be administered together with these drugs increasing costs and side-effects. We aimed to develop a predictive model of treatment response based on a combination of baseline clinical and viral parameters....
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