Article
LKB1 mutations frequently detected in mucinous bronchioloalveolar carcinoma.
Japanese journal of clinical oncology - 1 Sept 2011
Osoegawa Atsushi, Kometani Takuro, Nosaki Kaname, Ondo Kaoru, Hamatake Motoharu, Hirai Fumihiko, Seto Takashi, Sugio Kenji, Ichinose Yukito
Abstract excerpt
OBJECTIVE: LKB1 mutations are common in patients with Peutz-Jeghers syndrome, which is characterized by mucocutaneous pigmentation, intestinal polyps and a high incidence of cancers at variable sites. This study investigated the status of the LKB1 gene in mucinous bronchioloalveolar carcinoma with or without Peutz-Jeghers syndrome. METHODS: Three mucinous bronchioloalveolar carcinoma tumors from two Peutz-Jeghers...
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