Article
Genetic Screening and Analysis of LKB1 Gene in Chinese Patients with Peutz-Jeghers Syndrome.
Medical science monitor : international medical journal of experimental and clinical research - 10 Oct 2016
Chen Chunyan, Zhang Xiaomei, Wang Deqiang, Wang Fangyu, Pan Jian, Wang Zhenkai, Liu Chang, Wu Lin, Lu Heng, Li Nan, Wei Juan, Shi Hui, Wan Haijun, Zhu Ming, Chen Senqing, Zhou Yun, Zhou Xin, Yang Liu, Liu Jiong
Abstract excerpt
BACKGROUND Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic disease. It severely decreases patient quality of life and leads elevated cancer risk. Germline mutation of LKB1 is the leading cause of familial PJS. MATERIAL AND METHODS To characterize the germline mutation of LKB1 gene in Chinese familial and sporadic PJS patients, 14 PJS families, 5 sporadic PJS patients, and 250 healthy adults were...
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