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Article

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.

British journal of cancer - 22 Jul 2008

Koivunen J P, Kim J, Lee J, Rogers A M, Park J O, Zhao X, Naoki K, Okamoto I, Nakagawa K, Yeap B Y, Meyerson M, Wong K-K, Richards W G, Sugarbaker D J, Johnson B E, Jänne P A

Abstract excerpt

Somatic mutations of LKB1 tumour suppressor gene have been detected in human cancers including non-small cell lung cancer (NSCLC). The relationship between LKB1 mutations and clinicopathological characteristics and other common oncogene mutations in NSCLC is inadequately described. In this study we evaluated tumour specimens from 310 patients with NSCLC including those with adenocarcinoma, adenosquamous...

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Identifiers

PMID: 18594528
DOI: 10.1038/sj.bjc.6604469
PMCID: PMC2480968

Genes

EGFR
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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