Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LKB1 gene alterations in surgically resectable adenocarcinoma of the lung.

Surgery today - 1 Jan 2011

Okuda Katsuhiro, Sasaki Hidefumi, Hikosaka Yu, Kawano Osamu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

PURPOSE: Germline mutations of LKB1 (also known as SKT11; locus 19p13.3) cause the occurrence of autosomal dominant Peutz-Jeghers syndrome (PJS). Nearly half of the non-small cell lung cancer (NSCLC) cell lines and one-third of lung adenocarcinoma in Caucasian patients have an LKB1 mutation. METHODS: This study examined the mutational hot spots of the LKB1 gene in surgical resectable lung adenocarcinoma. Exons 1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to AMP-Activated Protein Kinase Kinases

Share to Lung Neoplasms

Share to Protein Serine-Threonine Kinases

Share to Sex Factors

Share to Smoking

Source

Identifiers

PMID: 21191700
DOI: 10.1007/s00595-009-4243-y

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LKB1 gene alterations in surgically resectable adenocarcinoma of the lung.PMID 21191700Read ↗

LKB1 gene mutations in Japanese lung cancer patients.Semantic proximity Read ↗

Prevalence and specificity of LKB1 genetic alterations in lung cancers.Semantic proximity Read ↗

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome.Semantic proximity Read ↗

Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas.Semantic proximity Read ↗

Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers.Semantic proximity Read ↗

Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.Semantic proximity Read ↗

Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in KRAS-Mutant Lung Adenocarcinoma.Semantic proximity Read ↗

LKB1 mutations frequently detected in mucinous bronchioloalveolar carcinoma.Semantic proximity Read ↗

Alterations of the LKB1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.Semantic proximity Read ↗

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.Semantic proximity Read ↗

LKB1, TP16, EGFR, and KRAS somatic mutations in lung adenocarcinomas from a Chiba Prefecture, Japan cohort.Semantic proximity Read ↗

Mutations in the human LKB1/STK11 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.