Article
Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2010
Gao Bin, Sun Yihua, Zhang Junhua, Ren Yan, Fang Rong, Han Xiangkun, Shen Lei, Liu Xin-Yuan, Pao William, Chen Haiquan, Ji Hongbin
Abstract excerpt
INTRODUCTION: Somatic LKB1 mutations are found in lung adenocarcinomas at different frequencies in Caucasian and East Asian (Japanese and Korean) populations. This study was designed to characterize the frequency of LKB1 mutations, their relationship to EGFR and KRAS mutations, and their associat...
Topics
- AMP-Activated Protein Kinase Kinases
- Adenocarcinoma
- Adult
- Asian People
- DNA
- ErbB Receptors
- Female
- Humans
- Loss of Heterozygosity
- Lung
- Lung Neoplasms
- Male
- Middle Aged
- Mutation