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Article

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome.

Oncogene - 13 Dec 2007

Sanchez-Cespedes M

Abstract excerpt

Germline LKB1 mutations are responsible for Peutz-Jeghers syndrome (PJS). Tumors at several locations frequently arise in these patients, confirming that LKB1 is linked to cancer predisposition and is therefore a bona fide tumor-suppressor gene. In humans, the LKB1 gene is located in the short arm of chromosome 19, which is frequently deleted in many tumors of sporadic origin. However, LKB1 alterations in tumors...

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Identifiers

PMID: 17599048
DOI: 10.1038/sj.onc.1210594

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