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Article

Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2013

Lee Su Man, Choi Jin Eun, Na Yeon Kyung, Lee Eun Jin, Lee Won Kee, Choi Yi Young, Yoon Ghil Suk, Jeon Hyo-Sung, Kim Dong Sun, Park Jae Yong

Abstract excerpt

INTRODUCTION: Liver kinase 1 (LKB1) plays a critical barrier role in lung tumorigenesis by controlling initiation, differentiation and metastasis. We searched for genetic and epigenetic alterations of the LKB1 gene in Korean non-small cell lung cancers (NSCLCs) and correlated the results with clinicopathological features. We also investigated the relationship between genetic and epigenetic alterations of LKB1 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23664447
DOI: 10.1016/j.lungcan.2013.04.013

Genes

EGFR

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