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Chronic lymphocytic leukemia: revelations from the B-cell receptor

17 Feb 2004

Abstract excerpt

The finding that chronic lymphocytic leukemia (CLL) consists of 2 clinical subsets, distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable region (V) genes, has clearly linked prognosis to biology. Antigen encounter by the cell of origin is indicated in both subsets by selective but distinct expression of V genes, with evidence for continuing stimulation after transformation. The...

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PMID: 14962897
DOI: 10.1182/blood-2003-12-4312

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