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The current understanding on the impact of KRAS on colorectal cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2021

Meng Mingjing, Zhong Keying, Jiang Ting, Liu Zhongqiu, Kwan Hiu Yee, Su Tao

Abstract excerpt

KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS mutations on the prognosis and survival of CRC patients drives many research studies to explore potential therapeutics or target therapy for the KRAS mutant CRC. This review summarizes the current understanding of the pathological consequences of...

Topics

Animals
Colorectal Neoplasms
Humans
Mutation
Proto-Oncogene Proteins p21(ras)

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34044280
DOI: 10.1016/j.biopha.2021.111717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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