Article
Noncooperative folding of subdomains in adenylate kinase.
Biochemistry - 10 Mar 2009
Rundqvist Louise, Adén Jörgen, Sparrman Tobias, Wallgren Marcus, Olsson Ulrika, Wolf-Watz Magnus
Abstract excerpt
Conformational change is regulating the biological activity of a large number of proteins and enzymes. Efforts in structural biology have provided molecular descriptions of the interactions that stabilize the stable ground states on the reaction trajectories during conformational change. Less is known about equilibrium thermodynamic stabilities of the polypeptide segments that participate in structural changes...
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