Article
Translational frameshifting generates the gamma subunit of DNA polymerase III holoenzyme.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Tsuchihashi Z, Kornberg A
Abstract excerpt
The dnaX gene (previously called dnaZX) of Escherichia coli has only one open reading frame for a 71-kDa polypeptide from which two distinct DNA polymerase III holoenzyme subunits, tau (71 kDa) and gamma (47 kDa), are produced. To determine how the gamma subunit is generated, we examined the influence of mutations in the dnaX gene on the pattern of tau and gamma production in overproducing cells. Important...
Topics
- Base Sequence
- Chromosome Deletion
- DNA Polymerase III
- DNA, Bacterial
- DNA-Directed DNA Polymerase
- Escherichia coli
- Gene Expression
- Genes, Bacterial
- Macromolecular Substances
- Molecular Sequence Data