Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trans-dominant mutations in the 3'-terminal region of the rpoB gene define highly conserved, essential residues in the beta subunit of RNA polymerase: the GEME motif.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 1999

Cromie K D, Ahmad K, Malik T, Buyukuslu N, Glass R E

Abstract excerpt

BACKGROUND: The multimeric DNA-dependent RNA polymerases are widespread throughout nature. The RNA polymerase of Escherichia coli, which is the most well characterized, consists of a holoenzyme with subunit stoichiometry of alpha2betabeta'sigma. The beta subunit is conserved and has been implicated in all stages of transcription. The extreme C-terminus of the beta subunit, which includes two well-conserved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genes, Bacterial

Share to Mutagenesis, Insertional

Share to Plasmids

Share to Structure-Activity Relationship

Share to Transcription, Genetic

Source

Identifiers

PMID: 10320480
DOI: 10.1046/j.1365-2443.1999.00248.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trans-dominant mutations in the 3'-terminal region of the rpoB gene define highly conserved, essential residues in the beta subunit of RNA polymerase: the GEME motif.PMID 10320480Read ↗

Isolation, purification, and in vitro characterization of recessive-lethal-mutant RNA polymerases from Escherichia coli.Semantic proximity Read ↗

Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity.Semantic proximity Read ↗

Antimutator mutations in the alpha subunit of Escherichia coli DNA polymerase III: identification of the responsible mutations and alignment with other DNA polymerases.Semantic proximity Read ↗

Physical mapping of a collection of Mael-generating amber mutations in the beta gene of Escherichia coli RNA polymerase and the functional effect of internal deletions constructed through their manipulation.Semantic proximity Read ↗

Localization of nusA-suppressing amino acid substitutions in the conserved regions of the beta' subunit of Escherichia coli RNA polymerase.Semantic proximity Read ↗

Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

The <i>E. coli</i> pathobiont LF82 encodes a unique variant of σ <sup>70</sup> that results in specific gene expression changes and altered phenotypesSemantic proximity Read ↗

Mutations in and monoclonal antibody binding to evolutionary hypervariable region of Escherichia coli RNA polymerase beta' subunit inhibit transcript cleavage and transcript elongation.Semantic proximity Read ↗

Identifying interacting regions in the beta subunit of Escherichia coli RNA polymerase.Semantic proximity Read ↗

Mutations in the CRE pocket of bacterial RNA polymerase affect multiple steps of transcription.Semantic proximity Read ↗

An altered-specificity DNA-binding mutant of Escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo.Semantic proximity Read ↗

In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.