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Article

Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Aug 2011

Dean Terry, Xu Rong, Joiner William, Sehgal Amita, Hoshi Toshinori

Abstract excerpt

The quiver/sleepless (qvr/sss) gene encodes a small, glycosylphosphatidylinositol-anchored protein that plays a critical role in the regulation of sleep in Drosophila. Loss-of-function mutations in qvr/sss severely suppress sleep and effect multiple changes in in situ Shaker K(+) currents, including decreased magnitude, slower time-to-peak, and cumulative inactivation. Recently, we demonstrated that SLEEPLESS...

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Identifiers

PMID: 21813698
DOI: 10.1523/JNEUROSCI.0502-11.2011
PMCID: PMC3183472

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Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.PMID 21813698Read ↗

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.Semantic proximity Read ↗

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Identification of SLEEPLESS, a sleep-promoting factor.Semantic proximity Read ↗

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Alterations in activation gating of single Shaker A-type potassium channels by the Sh5 mutation.Semantic proximity Read ↗

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Unmasking of a novel potassium current in Drosophila by a mutation and drugs.Semantic proximity Read ↗

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