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Article

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.

Nature neuroscience - 1 Jan 2010

Wu Mark N, Joiner William J, Dean Terry, Yue Zhifeng, Smith Corinne J, Chen Dechun, Hoshi Toshinori, Sehgal Amita, Koh Kyunghee

Abstract excerpt

Sleep is a whole-organism phenomenon accompanied by global changes in neural activity. We previously identified SLEEPLESS (SSS) as a glycosylphosphatidyl inositol-anchored protein required for sleep in Drosophila. Here we found that SSS is critical for regulating the sleep-modulating potassium channel Shaker. SSS and Shaker shared similar expression patterns in the brain and specifically affected each other's...

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Identifiers

PMID: 20010822
DOI: 10.1038/nn.2454
PMCID: PMC2842941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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