Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.

Abstract excerpt

Regulation of synaptic efficacy by nerve terminal excitability has not been extensively studied. We performed genetic and pharmacological dissections for presynaptic actions of K+ channels in Drosophila neuromuscular transmission by using electrophysiological and optical imaging techniques. Current understanding of the roles of the Shab IK channel and its mammalian Kv2 counterparts is relatively poor, as compared...

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