Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants.

Molecular psychiatry - 1 Feb 2015

Chen W-F, Maguire S, Sowcik M, Luo W, Koh K, Sehgal A

Abstract excerpt

Sleep is an essential process and yet mechanisms underlying it are not well understood. Loss of the Drosophila quiver/sleepless (qvr/sss) gene increases neuronal excitability and diminishes daily sleep, providing an excellent model for exploring the underpinnings of sleep regulation. Here, we used a proteomic approach to identify proteins altered in sss brains. We report that loss of sleepless...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Gene Expression Regulation

Share to Membrane Proteins

Share to Neuroglia

Share to Neurons

Source

Open in PubMed Open full text

Identifiers

PMID: 24637426
DOI: 10.1038/mp.2014.11
PMCID: PMC4168011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants.PMID 24637426Read ↗

Identification of SLEEPLESS, a sleep-promoting factor.Semantic proximity Read ↗

Neuronal machinery of sleep homeostasis in Drosophila.Semantic proximity Read ↗

DBT affects sleep in both circadian and non-circadian neurons.Semantic proximity Read ↗

Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila.Semantic proximity Read ↗

Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.Semantic proximity Read ↗

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.Semantic proximity Read ↗

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.Semantic proximity Read ↗

The genetic and molecular regulation of sleep: from fruit flies to humans.Semantic proximity Read ↗

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.Semantic proximity Read ↗

Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila.Semantic proximity Read ↗

Identifying sleep regulatory genes using a Drosophila model of insomnia.Semantic proximity Read ↗

Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.