Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of SLEEPLESS, a sleep-promoting factor.

Science (New York, N.Y.) - 18 Jul 2008

Koh Kyunghee, Joiner William J, Wu Mark N, Yue Zhifeng, Smith Corinne J, Sehgal Amita

Abstract excerpt

Sleep is an essential process conserved from flies to humans. The importance of sleep is underscored by its tight homeostatic control. Through a forward genetic screen, we identified a gene, sleepless, required for sleep in Drosophila. The sleepless gene encodes a brain-enriched, glycosylphosphat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Insect
Share to Glycosylphosphatidylinositols
Share to Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Animal

Share to Shaker Superfamily of Potassium Channels

Share to Sleep Deprivation

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 18635795
DOI: 10.1126/science.1155942
PMCID: PMC2771549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18635795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of SLEEPLESS, a sleep-promoting factor.PMID 18635795Read ↗

SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.Semantic proximity Read ↗

A neuron-glia interaction involving GABA transaminase contributes to sleep loss in sleepless mutants.Semantic proximity Read ↗

Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels.Semantic proximity Read ↗

Reduced sleep in Drosophila Shaker mutants.Semantic proximity Read ↗

A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79Semantic proximity Read ↗

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.Semantic proximity Read ↗

The genetic and molecular regulation of sleep: from fruit flies to humans.Semantic proximity Read ↗

DBT affects sleep in both circadian and non-circadian neurons.Semantic proximity Read ↗

Identifying sleep regulatory genes using a Drosophila model of insomnia.Semantic proximity Read ↗

Forward-genetics analysis of sleep in randomly mutagenized mice.Semantic proximity Read ↗

Neuronal machinery of sleep homeostasis in Drosophila.Semantic proximity Read ↗

From genetics to structure to function: exploring sleep in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.