Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study.

doi:10.1182/blood-2009-07-234229

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Article

Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study.

Blood - 15 Apr 2010

Coyaud Etienne, Struski Stephanie, Prade Nais, Familiades Julien, Eichner Ruth, Quelen Cathy, Bousquet Marina, Mugneret Francine, Talmant Pascaline, Pages Marie-Pierre, Lefebvre Christine, Penther Dominique, Lippert Eric, Nadal Nathalie, Taviaux Sylvie, Poppe Bruce, Luquet Isabelle, Baranger Laurence, Eclache Virginie, Radford Isabelle, Barin Carole, Mozziconacci Marie-Joëlle, Lafage-Pochitaloff Marina, Antoine-Poirel Hélène, Charrin Christiane, Perot Christine, Terre Christine, Brousset Pierre, Dastugue Nicole, Broccardo Cyril

Abstract excerpt

PAX5 is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). We analyzed 153 adult and child B-ALL harboring karyotypic abnormalities at chromosome 9p, to determine the frequency and the nature of PAX5 alterations. We found PAX5 internal rearrangements in 21% of the cas...

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Identifiers

PMID: 20160164
DOI: 10.1182/blood-2009-07-234229

Genes

PAX5
DACH2
TAOK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20160164-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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