Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations.

doi:10.1200/JCO.2011.35.3979

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Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2011

Yuan Shinsheng, Yu Sung-Liang, Chen Hsuan-Yu, Hsu Yi-Chiung, Su Kang-Yi, Chen Huei-Wen, Chen Chih-Yi, Yu Chong-Jen, Shih Jin-Yuan, Chang Yih-Leong, Cheng Chiou-Ling, Hsu Chung-Ping, Hsia Jiun-Yi, Lin Chien-Yu, Wu Guani, Liu Chia-Hsin, Wang Chin-Di, Yang Kang-Chung, Chen Yi-Wei, Lai Yi-Ling, Hsu Chu-Chun, Lin Tai-Ching, Yang Tsung-Ying, Chen Kun-Cheieh, Hsu Kuo-Hsuan, Chen Jeremy J W, Chang Gee-Chen, Li Ker-Chau, Yang Pan-Chyr

Abstract excerpt

PURPOSE: Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been proven more effective for patients with lung adenocarcinoma with EGFR-activating mutation rather than wild type, the former group still includes approximately 30% nonresponders. The molecular basis of this substantial response heterogeneity is unknown. Our purpose was to seek molecular aberrations contributing to...

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PMID: 21810691
DOI: 10.1200/JCO.2011.35.3979

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