Article
Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes.
BMC cancer - 5 Jan 2013
Ninomiya Hironori, Kato Motohiro, Sanada Masashi, Takeuchi Kengo, Inamura Kentaro, Motoi Noriko, Nagano Hiroko, Nomura Kimie, Sakao Yukinori, Okumura Sakae, Mano Hiroyuki, Ogawa Seishi, Ishikawa Yuichi
Abstract excerpt
BACKGROUND: A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients. METHODS: To gain insights into etiology and carcinogenic mechanisms we conducted analyses to compare allelotypes of 35...
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