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Article

Pin1 deficiency causes endothelial dysfunction and hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2011

Chiasson Valorie L, Munshi Nidhi, Chatterjee Piyali, Young Kristina J, Mitchell Brett M

Abstract excerpt

Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation. We have shown previously that deficiency of another peptidyl prolyl isomerase, FK506 binding protein 12/12.6, alters endothelial NO synthase phosphorylation and causes endothelial dysfunction and...

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Identifiers

PMID: 21810655
DOI: 10.1161/HYPERTENSIONAHA.111.172338
PMCID: PMC4096767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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