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Article

eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity.

Biochemical and biophysical research communications - 8 Feb 2013

Kashiwagi Satoshi, Atochin Dmitriy N, Li Qian, Schleicher Michael, Pong Terrence, Sessa William C, Huang Paul L

Abstract excerpt

Phosphorylation of endothelial nitric oxide synthase (eNOS) is an important regulator of its enzymatic activity. We generated knockin mice expressing phosphomimetic (SD) and unphosphorylatable (SA) eNOS mutations at S1176 to study the role of eNOS phosphorylation. The single amino acid SA mutation is associated with hypertension and decreased vascular reactivity, while the SD mutation results in increased basal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23291238
DOI: 10.1016/j.bbrc.2012.12.110
PMCID: PMC3576142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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