Pleiotropic effects of GIP on islet function involve osteopontin.

doi:10.2337/db10-1532

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Article

Pleiotropic effects of GIP on islet function involve osteopontin.

Diabetes - 1 Sept 2011

Lyssenko Valeriya, Eliasson Lena, Kotova Olga, Pilgaard Kasper, Wierup Nils, Salehi Albert, Wendt Anna, Jonsson Anna, De Marinis Yang Z, Berglund Lisa M, Taneera Jalal, Balhuizen Alexander, Hansson Ola, Osmark Peter, Dunér Pontus, Brøns Charlotte, Stancáková Alena, Kuusisto Johanna, Bugliani Marco, Saxena Richa, Ahlqvist Emma, Kieffer Timothy J, Tuomi Tiinamaija, Isomaa Bo, Melander Olle, Sonestedt Emily, Orho-Melander Marju, Nilsson Peter, Bonetti Sara, Bonadonna Riccardo, Miccoli Roberto, Delprato Stefano, Marchetti Piero, Madsbad Sten, Poulsen Pernille, Vaag Allan, Laakso Markku, Gomez Maria F, Groop Leif

Abstract excerpt

OBJECTIVE: The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we...

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Identifiers

PMID: 21810601
DOI: 10.2337/db10-1532
PMCID: PMC3161325

Genes

GIP
GIPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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