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GLP1R Single-Nucleotide Polymorphisms rs3765467 and rs10305492 Affect β Cell Insulin Secretory Capacity and Apoptosis Through GLP-1.

DNA and cell biology - 1 Sept 2020

Li Weizheng, Li Pengzhou, Li Rao, Yu Zhaomei, Sun Xulong, Ji Guangnian, Yang Xiangwu, Zhu Liyong, Zhu Shaihong

Abstract excerpt

The increased secretion of glucagon-like peptide-1 (GLP-1) after Roux-en-Y gastric bypass (RYGB) is regarded as the main reason for the improvement of blood glucose. However, the single-nucleotide polymorphisms (SNPs) of GLP-1 Receptor (GLP1R) impair receptor function, subsequently affecting β cell insulin secretion function, ultimately affecting the efficacy of RYGB. In this study, we revealed that two SNPs in...

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PMID: 32721233
DOI: 10.1089/dna.2020.5424

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