Article
Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells.
Archives of biochemistry and biophysics - 30 Sept 2020
da Silva Inês Vieira, Cardoso Carlos, Méndez-Giménez Leire, Camoes Sérgio Povoas, Frühbeck Gema, Rodríguez Amaia, Miranda Joana Paiva, Soveral Graça
Abstract excerpt
Aquaporins (AQPs) facilitate water and glycerol movement across membranes. AQP7 is the main aquaglyceroporin in pancreatic β-cells and was proposed to play a role in insulin exocytosis. Although AQP7-null mice display adult-onset obesity, impaired insulin secretion and insulin resistance, AQP7 loss-of-function homozygous mutations in humans do not correlate with obesity nor type-2 diabetes. In addition, AQP12 is...
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