Article
A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B.
PLoS genetics - 1 Feb 2017
Soboleva Tatiana A, Parker Brian J, Nekrasov Maxim, Hart-Smith Gene, Tay Ying Jin, Tng Wei-Quan, Wilkins Marc, Ryan Daniel, Tremethick David J
Abstract excerpt
The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B appeared late in evolution and is most highly expressed in the testis followed by the brain in mammals. This raises the question of what new function(s) H2A.B might impart to chromatin in these important tissues. We have immunoprecipitated the mouse orthologue...
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